Memory Formation

Synaptic connections may be modified by many different forms of plasticity or adaptive processes. At some hippocampal synapses, such as the perforant path to granule cell synapse, long-term potentiation (LTP) is observed to decay over a period of days or weeks. LTP has attracted a great deal of interest as a possible synaptic mechanism of both learning and memory. NMDA, AMPA and metabotropic gluta-mate receptors are involved in the induction of LTP. Inhibitors of protein kinase C and CaMK II can decrease the induction of LTP. In addition, the phenomenon of long-term depression (LTD) is generally defined as a lasting , non pathological decrease in the strength of synaptic transmission. Several forms of hippocampal synaptic plasticity are dependent on calcium, providing a potential link between altered calcium homeostasis and memory deficits. Finally, psychosocial factors can have significant positive and negative effects on hippocampal structure and function.

Orestis Giotakos

Click here to see the full Article.