Clinical neuroscience and mental health: filling the gap


Recent developments in neuroscience can help inform clinicians› understanding of cognition, emotion, behavior, and social interactions—all critical aspects of people›s lives that are dramatically a!ected in psychiatric disorders. Psychiatry is informed by a broad range of basic biological and social sciences and has at its disposal many tools, like brain imaging, genetics, neuropsychopharmacology, neurophysiology, epidemiological models, and neuropsychology, for developing new assessment and treatment approaches, grounded in understanding […]

Is impulsivity in part a lithium deficiency state?

Lithium mechanisms of action are related to the function of many enzymes, hormones, vitamins, and growth factors. In humans, lithium treatment has been associated with humoral and structural evidence of neuroprotection, such as increased expression of antiapoptotic genes, inhibition of cellular oxidative stress, synthesis of brain-derived neurotrophic factor, cortical thickening, increased grey matter density, and hippocampal enlargement. Lithium, in pharmacological doses, has been used successfully in treating bipolar […]

Is there a connection between lithium induced hypothyroidism and lithium efficacy in bipolar disorder?


Hypothyroidism, more commonly subclinical, appears a common abnormality, while the hypothalamic-pituitary-thyroid (HPT) axis abnormalities are quite common among patients with bipolar disorder. On the other hand, lithium has been used successfully in treating bipolar disorders, but lithium influence on the thyroid gland is one of the key side effects in the long-term therapy. Lithium administration leads to a decrease of production and release of thyroid hormones, which results […]